AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN KELOR (Moringa oleifera L.) DAN PENGEMBANGANNYA MENJADI BENTUK SEDIAAN GEL

Nur Asisi, Uliyah Uliyah, Nurul Fitrah Amaliyah, A. Hasrawati

Abstract


Antioxidants are used to prevent the oxidation of free radical compounds which have a bad impact on the body, including the skin.  One source of antioxidants derived from natural ingredients is Moringa leaves.  Moringa leaves have a number of benefits due to the many active chemical compounds.  The antioxidant activity of Moringa leaves can be optimized by developing Moringa leaves into a gel dosage form.  A literature review regarding the compound content and activity of Moringa leaves was carried out to obtain scientific data that can be used in the development of Moringa leaves as an antioxidant.  Narrative review with data sources from Science Direct, Pubmed, CiterSeerX, and Google Scholars. The Inclusion and exclusion criteria were set to obtain literature according to the scope of the study.  The results of the literature review showed that Moringa leaves contain the main active compounds of polyphenols and flavonoids which have strong antioxidant activity.  Gel dosage form is one of the best choices to optimize the antioxidant activity of Moringa leaves.  HPMC, carbopol and xanthan gum are gelling agent was produced a gel preparation with good pharmaceutical characteristics.


Keywords


Antioxidant, Moringa Leaf, Polyphenol, Flavonoid, Gel.

References


Wahdaningsih S, Setyowati EP, Wahyuono S. Aktivitas Penangkap Radikal Bebas Dari Batang Pakis (Alsophila glauca J. Sm). Maj Obat Tradisional, 2011; 16(3): 156-160.

Lephart ED. Skin aging and oxidative stress: Equol’s anti-aging effects via biochemical and molecular mechanisms. Ageing Res Rev, 2016; 31: 36–54.

Sari AN, Si M. Antioksidan Alternatif untuk Menangkal Bahaya Radikal Bebas pada Kulit. J Islam Sci Technol, 2015; 1: 63–68.

Álvarez-Román R, Silva-Flores PG, Galindo-Rodríguez SA, et al. Moisturizing and antioxidant evaluation of Moringa oleifera leaf extract in topical formulations by biophysical techniques. South African J Bot, 2020; 129: 404–411.

Draelos ZD, Thaman LA. Cosmetic Formulation of Skin Care Products. 2010.

Garre A, Narda M, Valderas-Martinez P, et al. Antiaging effects of a novel facial serum containing l-ascorbic acid, proteoglycans, and proteoglycan-stimulating tripeptide: Ex vivo skin explant studies and in vivo clinical studies in women. Clin Cosmet Investig Dermatol, 2018; 11: 253–263.

Lund W. The Pharmaceutical Codex Twelfth Edition Principles and Practice of Pharmaceutics. The Pharmaceutical Press.1994.

Matshediso PG, Cukrowska E, Chimuka L. Development of pressurised hot water extraction (PHWE) for essential compounds from Moringa oleifera leaf extracts. Food Chem, 2015; 172: 423–427.

Suphachai C. Antioxidant and anticancer activities of Moringa oleifera leaves. J Med Plants Res 2014; 8: 318–325.

Shahriar M, Hossain MI, Bahar ANM, et al. Preliminary phytochemical screening, in-vitro antioxidant and cytotoxic activity of five different extracts of Moringa oleifera leaf. J Appl Pharm Sci, 2012; 2: 65–68.

Baldisserotto A, Buso P, Radice M, et al. Moringa oleifera leaf extracts as multifunctional ingredients for “natural and organic” sunscreens and photoprotective preparations. Molecules; 23. Epub ahead of print 2018. DOI: 10.3390/molecules23030664.

Ademiluyi AO, Aladeselu OH, Oboh G, et al. Drying alters the phenolic constituents, antioxidant properties, α-amylase, and α-glucosidase inhibitory properties of Moringa (Moringa oleifera) leaf. Food Sci Nutr, 2018; 6: 2123–2133.

Fitriana WD, Ersam T, Shimizu K, et al. Antioxidant activity of Moringa oleifera extracts. Indones J Chem, 2016; 16: 297–301.

Vongsak B, Sithisarn P, Mangmool S, et al. Maximizing total phenolics, total flavonoids contents and antioxidant activity of Moringa oleifera leaf extract by the appropriate extraction method. Ind Crops Prod, 2013; 44: 566–571.

Pelen S, Wullur A, Citraningtyas G. Formulasi Sediaan Gel Antijerawat Minyak Atsiri Kulit Batang Kayu Manis (Cinnamomum Burmanii) Dan Uji Aktivitas Terhadap Bakteri Staphylococcus Aureus. Pharmacon, 2016; 5: 136–144.

Yusuf AL, Nurawaliah E, Harun N. Uji efektivitas gel ekstrak etanol daun kelor (Moringa oleifera L.) sebagai antijamur Malassezia furfur. Kartika J Ilm Farm, 2017; 5: 62.

Hasanah U, Yusriadi Y, Khumaidi A. Formulasi Gel Ekstrak Etanol Daun Kelor (Moringa oleifera Lam) Sebagai Antioksidan. Nat Sci J Sci Technol, 2017; 6: 46–57.

Hasrawati A, Aztriana. Pengembangan Gel Ekstrak Etanol Cabai Rawit (Capsicum frutescence L). Angew Chemie Int Ed 6(11), 951–952. 2017;08(01):1–77.

Hasrawati, A., Hardianti, H., Qama, A. and Wais, M. Pengembangan Ekstrak Etanol Limbah Biji Pepaya (Carica papaya L.) Sebagai Serum Antijerawat. Jurnal Fitofarmaka Indonesia, 2020; 7(1):1-8.




DOI: https://doi.org/10.56711/jifa.v13i1.757

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ISSN: 2085-4714 | e-ISSN: 2502-9444

Editor's Address:

Faculty of Pharmacy, Univeristas Muslim Indonesia
2nd Campus of UMI: Jl. Urip Sumoharjo km. 5 , Makassar, South Sulawesi, Indonesia

E-mail: jurnal.farmasi@umi.ac.id

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