ANTIBACTERIAL ACTIVITY TEST OF COMBINATION OF BETEL LEAF EXTRACT (PIPER BETLE) AND KERSEN LEAF EXTRACT (MUNTINGIA CALABURA) AGAINST ESCHERICHIA COLI BACTERIA
DOI:
https://doi.org/10.56711/jms.v2i2.829Abstract
Escherichia coli or commonly referred to as E. coli is a Gram-negative bacteria that can cause various problems in the human body, the mechanism of resistance built by E.Coli to antibiotics is a reason for the need to look for compounds that have antibacterial potential. Betel leaf and cherry leaf are two types of plants that have the potential to have compounds that can be developed as antibacterial, this study tested the two types of plants using the disc diffusion method. The compounds identified in this plant are alkaloids, saponins, and flavonoids. These three compounds are thought to provide strong antibacterial activity in the samples, although further research is still needed to confirm this.
References
Kaper JB, Nataro JP, Mobley HLT. Pathogenic Escherichia coli. Nat Rev Microbiol 2004; 2: 123–140.
Pakbin B, Brück WM, Rossen JWA. Virulence Factors of Enteric Pathogenic Escherichia coli: A Review. International Journal of Molecular Sciences ; 22. Epub ahead of print 2021. DOI: 10.3390/ijms22189922.
Laurent P, Jean-Yves M, Agnese L, et al. Antimicrobial Resistance in Escherichia coli. Microbiol Spectr 2018; 6: 6.4.14.
Row L-CM, Ho J-C. The Antimicrobial Activity, Mosquito Larvicidal Activity, Antioxidant Property and Tyrosinase Inhibition of Piper Betle. J Chinese Chem Soc 2009; 56: 653–658.
Surjowardojo P, Setyowati E, Ambarwati I. Antibacterial Effects of Green Betel ( Piper betle Linn .) Leaf Against. AGRIVITA J Agric Sci 2019; 41: 569–574.
Mahmood ND, Nasir NLM, Rofiee MS, et al. Muntingia calabura: A review of its traditional uses, chemical properties, and pharmacological observations. Pharm Biol 2014; 52: 1598–1623.
Amelinda E, Widarta IWR, Darmayanti LPT. PENGARUH WAKTU MASERASI TERHADAP AKTIVITAS ANTIOKSIDAN EKSTRAK RIMPANG TEMULAWAK (Curcuma xanthorriza Roxb.). J Ilmu dan Teknol Pangan 2018; 7: 165.
Hassan A, Akmal Z, Khan N, et al. The Phytochemical Screening and Antioxidants Potential of Schoenoplectus triqueter L. Palla. J Chem; 2020. Epub ahead of print 2020. DOI: 10.1155/2020/3865139.
Mostafa AA, Al-Askar AA, Almaary KS, et al. Antimicrobial activity of some plant extracts against bacterial strains causing food poisoning diseases. Saudi J Biol Sci 2018; 25: 361–366.
Yan Y, Li X, Zhang C, et al. Research progress on antibacterial activities and mechanisms of natural alkaloids: A review. Antibiotics; 10. Epub ahead of print 2021. DOI: 10.3390/antibiotics10030318.
Tagousop CN, Tamokou J de D, Kengne IC, et al. Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes. Chem Cent J 2018; 12: 1–9.
Xie Y, Yang W, Tang F, et al. Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism. Current Medicinal Chemistry 2015; 22: 132–149.
FITRI L, BUSTAM BM. Screening of antimicrobial producing strains isolated from the soil of grassland rhizosphere in Pocut Meurah Intan Forest Park, Seulawah, Aceh Besar. Biodiversitas J Biol Divers; 11. Epub ahead of print 2010. DOI: 10.13057/biodiv/d110305.
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