POTENTIAL PEGAGAN LEAVES (CENTELLA ASIATICA (L.)) AS BURN HEALER AND ANTIBACTERIAL AGAINST STAPHYLOCOCCUS AUREUS

Fadila Fauzia Mutmaina Ulupalu, Rizqi Nur Azizah, Sukmawati Sukmawati

Sari


Pegagan leaves (Centella asiatica (L.)) in the know contain flavonoids, saponins tannin and asiaticosides which have the effect of wound healing and antibacterial. This research aims to review scientific articles related to the potential of pegagan leaves in healing burns and as an antibacterial against Staphylococcus aureus. In this study using the literature study method where articles were obtained from the Google Scholar database, then obtained 10 articles that fit the inclusion and exclusion criteria. The review results show that pegagan leaves have activity in healing burn and antibacterial activity against Staphylococcus aureus because they contain asiatic acid, saponins, flavonoids and tannins. The conclusion of this study is that pegagan leaves have the potential as wound healing of burns with an effective extract concentration of ethanol extract concentration of 25 % and ethyl acetate extract 0.33 % and pegagan leaves potentially as antibacterial to Staphylococcus aureus with effective extract concentrations, viz ethanol extract concentrations of 100 % and ethyl acetate extracts of concentrations of 70 %.

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Jeschke MG, van Baar ME, Choudhry MA, et al. Burn injury. Nature Review Disease Primers Article citation. 2020; 6(11). DOI: 10.1038/s41572-020-0145-5

Ardabili FM, Abdi S, Ghezeljeh TN, et al. Evaluation Of The Effects Of Patient-Selected Music Therapy On The Sleep Quality And Pain Intensity Of Burn Patients. Med - Surgical Nursing Journal. 2016; 5(2): 27–34

Theoret C. Physiology of Wound Healing in Equine Wound Management. 3thEd. 2017

Ekawati ER. Bakteriologi : Mikroorganisme Penyebab Infeksi. Yogyakarta : Deepublish. 2018

Anu HV, Amat ALS, Sasputra IN. Perbandingan Efektivitas Ekstrak Pegagan ( Centella asiatica ( L .) URBAN ) Dengan Salep Gentamisin Terhadap Penyembuhan Luka Insisi Tikus Putih Sprague dawley. Cendana Medical Journal. 2019; 18(3): 472–478

Vinolina, NS. Pegagan (Centella asiatica L. Urban) Dan Metabolit Sekundernya. Medan : Yayasan Kita Menulis. 2021

Somboonwong J, Kankaisre M, Tantisira B, et al. Wound Healing Activities Of Different Extracts Of Centella asiatica In Incision And Burn Wound Models: An Experimental Animal Study. BMC Complementary and Alternative Medicine. 2012; 12(103): 1

Artawan I. Efek Ekstrak Gel Daun Pegagan (Centella asiatica) Dalam Mempercepat Waktu Penyembuhan Luka Pada Tikus Putih (Rattus norvegicus Strain Wistar). Open J Syst. 2013; 1(2): 1–6

Widianingtyas D, Wihastuti TA, Setijowati N. Pengaruh Perawatan dengan Ekstrak Daun Pegagan (Centella asiatica ) dalam Mempercepat Penyembuhan Luka Bakar Derajat 2 Dangkal pada Tikus Putih ( Rattus norvegicus ) Strain Wistar. Majalah Kesehatan FKUB. 2014; 1(4): 223–227

Amaliya S, Soematri B, Utami YW. Efek Ekstrak Daun Pegagan (Centella asiatica) Dalam Mempercepat Penyembuhan Luka Terkontaminasi Pada Tikus Putih (Rattus novergicus) Galur Wistar. Jurnal Ilmu Keperawatan. 2013; 1(1): 19–25

Kurnianto S, Kusnanto K, Padoli P. Penyembuhan Luka Bakar Pada Tikus Putih Dengan Menggunakan Ekstrak Daun Pegagan (Centella asiatica) 25% Dan Ekstrak Daun Petai Cina (Leucaena leucocephala) 30%. Jurnal Ilmiah Kesehatan. 2018; 10(2): 250-255. DOI: 10.33086/jhs.v10i2.137

Darmalaksana IGN, Sudimantini LM, Jayawarditha AAG, et al. Gerusan Daun Pegagan Mempercepat Kesembuhan Luka Bakar pada Tikus Putih. Bul Vet Udayana. 2018; 10(2): 137-146

Stone R, Natesan S, Kowalczewski CJ, et al. Advancements In Regenerative Strategies Through The Continuum Of Burn Care. Front Pharmacol. 2018; 9: 672. DOI: 10.3389/fphar.2018.00672

Widiastuti R, Nurhaeni R, Dian Luluk Marfuah GSW. Potensi Antibakteri Dan Anticandida Ekstrak Etanol Daun Pegagan (Centella asiatica (L) Urb.). Jurnal Ilmu Kesehatan Bhakti Setya Medika. 2016; 1(1)

Nurrosyidah IH, Hermawati R AM. Uji Aktivitas Antibakteri Sediaan Gel Ekstrak Etanol Pegagan (Centela asiatica L.) Terhadap Bakteri Staphylococcus aureus Secara In Vitro. J Pharm Care Anwar Med 2019; 1(2): 45–57

Susanto DS RR. Studi Kandungan Bahan Aktif Tumbuhan Meranti Merah (Shorea leprosula Miq) Sebagai Sumber Senyawa Antibakteri. Mulawarmnan Sci. 2012; 11(2): 181–190

Sitepu R, Nurdiani R RR. Aplikasi Metode Bioautografi Dalam Penelusuran Daya Antibakteri Ekstrak Pegagan (Centella asiatica (L.)). J Katalisator. 2020; 5: 32–46

Murdiyansah S, Citra Rasmi DA, Mertha IG. Centella asiatica Activities towards Staphylococcus aureus and Escherichia coli Growth. J Biologi Tropis. 2020; 20(3): 499–506

Raudah S & Kamil WL. Pengaruh Ekstrak Daun Pegagan (Centella asiatica (L.) Urban) Terhadap Pertumbuhan Bakteri Staphylococcus aureus Pada Luka Penderita Diabetes Mellitus Secara Invitro. Jurnal Medika Karya Ilmiah Kesehatan. 2020; 5(1): 1–11

Belcaro G, Maquart FX, Scoccianti M, Dugall M, Hosoi M, Cesarone MR, Luzzi R, Cornelli U, Ledda A FB. TECA (Titrated Extract of Centella

asiatica): New Microcirculatory, Biomolecular, And Vascular Application In Preventive And Clinical Medicine. A status paper. Panminerva Med. 2011; 1: 105–118

Palumpun EF, Wiraguna AA PW. Pemberian ekstrak daun sirih (Piper betle) secara topikal meningkatkan ketebalan epidermis, jumlah fibroblas, dan jumlah kolagen dalam proses penyembuhan luka pada tikus jantan galur Wistar (Rattus norvegicus). eBiomedik. 2017; 5(1)

Sieberi BM, Omwenga GI, Wambua RK, et al. Screening of the Dichloromethane: Methanolic Extract of Centella asiatica for Antibacterial Activities against Salmonella typhi, Escherichia coli, Shigella sonnei, Bacillus subtilis, and Staphylococcus aureus. Sci World J. 2020. DOI: 10.1155/2020/6378712

Yudistira, F. A., Sri, M., Pratiwi T. Potensi Antimikroba Ekstrak Air Daun Kelor (Moringa oeifera) terhadap Salmonella enteridis (SP_1-PKH) secara In Vitro. Universitas Brawijaya. 2013




DOI: https://doi.org/10.56711/jms.v2i2.862

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