Isolasi Dan Identifikasi Senyawa Kimia Monoterpen Dari Fraksi Etilasetat Daun Keji Beling (Strobilanthes crispa (L.) Blume) Yang Mempunyai Daya Sitotoksik

Authors

  • Lilik Sulastri Sekolah Tinggi Teknologi Industri dan Farmasi (STTIF), Bogor
  • Ristanti Mega Lestari Sekolah Tinggi Teknologi Industri dan Farmasi (STTIF), Bogor
  • Partomuan Simanjuntak Puslit Kimia, Lembaga Ilmu Pengetahua Indonesia (LIPI), Serpong, Tangerang Selatan

DOI:

https://doi.org/10.33096/jffi.v8i1.721

Keywords:

D-limonene, monoterpene, keji Beling, Strobilanthus crispa (L.) Blume, cytotoxic

Abstract

Isolation and identification one of chemical compound mono-terpene from Keji beling plant (local name) (Strobilanthes crispa) has been done. Extraction was carried out by maceration of the keji beling leaf powder with ethanol 96%, then partitioned with water-ethyl acetate. Ethylacetate extract was isolated and purified by a cytotoxic guide fractionation system with Brine Shrimp Lethality Test (BSLT) on column chromatography (SiO2; n-hexane - ethylacetate = 20 : 1); and preparative Thin Layer Chromatography (TLC) (SiO2; n-hexane - ethylaseate = 10 : 1) which gave one compound in oily form.  Based on identification by infra red spectra and gas chromatography-mass spectra (GC-MS), the compound is a monoterpene D-limone which has a cytotoxic power of 73,11 ppm.

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Published

2021-01-29

Issue

Vol. 8 No. 1 (2021): JURNAL FITOFARMAKA INDONESIA

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