UJI IN VITRO DAN IN SILICO SENYAWA 5,7,2’,5’-TETRAHYDROXY FLAVAN-3-OL TERHADAP ENZIM ALPHA GLUCOSIDASE

Authors

  • Frengki Frengki Biomedik Fakultas Kedokteran Universitas Andalas-Padang FKH Universitas Syiah Kuala-Banda Aceh
  • Deddi Prima Fakultas Farmasi, Universitas Andalas
  • Fatma Sri Wahyuni Fakultas Farmasi, Universitas Andalas
  • Daan Khambri Fakultas Farmasi, Universitas Andalas
  • Henny Vanda Biomedik Fakultas Kedokteran, Universitas Andalas-Padang
  • Noni Zakiah Akademi Farmasi-Aceh Besar
  • Jamilah Abbas LIPI-Kimia Puspitek-Serpong
  • Berna Elya Fakultas Farmasi Universitas Indonesia

DOI:

https://doi.org/10.33096/jffi.v5i2.416

Abstract

Several of Calophyllums genus have been searched and proven as medicinal plants and Calophyllum macrophyllum is one of its genus. We have been isolated a compound from ethyl acetate fraction of the stem-bark. The compound was flavan-3-ol (5,7,2’,5’-tetrahydroxy flavan-3-ol). This research aimed to determine inhibition antidiabetic activity and affinity of its compound on α-glycosidase enzyme. In vitro antidiabetic effect shown by IC50 9.10 µg/ml and docking by Arguslab 4.01 shown by ΔG -10,24 kkal/mol as in silico test. The inhibition activity of flavan-3-ol against the α-glucosidase enzyme that is very strong shows its promising potential as a candidate for antidiabetic drugs.

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Published

2018-09-26

Issue

Vol. 5 No. 2 (2018): JURNAL FITOFARMAKA INDONESIA

Section

Articles

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