Postprandial Bioassay and Radical Scavenging on n-Hexane Fraction of Cordia myxa L. Leaf

Virsa Handayani, Aktsar Roskiana Ahmad, Nur Rezky Khairun Nisaa, La Hamidu, Ahmad Najib


Cordia myxa L. is empirically used as an antidiabetic medication. The aim of this study is to determine the in-vivo effect of Cordia myxa L. n-hexane fraction on reducing blood sugar levels and their relationship with the anti-free-radical activity assay using DPPH (1,1-diphenyl-2-Picrylhydrazyl). The n-hexane fraction of Cordia myxa L. was used as a sample in the post-prandial assay which was analyzed using the ANOVA statistical test followed by Post-Hoc test. The results showed that there were significant in the extract using a 500 mg dose. In the anti-free-radical test using DPPH (1,1-diphenyl-2-Picrylhydrazyl) at maximum wavelength of 516 nm, 16.49 µg /mL IC50 value was obtained. For comparison, Quercetin with IC50 0.13 µg/mL was used. This shows that the sample has strong anti-free radical inhibitory potential ranged from 10 µg/mL to 50 µg/mL. The data from the calculation showed that there is a correlation between its effect of lowering high blood sugar level and anti-free radical activity

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