EFEK HEPATOPROTEKTOR ANDROGRAPHOLIDE TERHADAP AKTIVITAS ALANIN AMINOTRANSFERASE DALAM SERUM Rattus norvegicus JANTAN GALUR WISTAR YANG DIINDUKSI KARBON TETRAKLORIDA

Dewinta Putri Utami; Andriani Andriani; Mardhia Mardhia; Virhan Novianry; Mistika Zakiah

doi:10.33096/jffi.v8i1.582

EFEK HEPATOPROTEKTOR ANDROGRAPHOLIDE TERHADAP AKTIVITAS ALANIN AMINOTRANSFERASE DALAM SERUM Rattus norvegicus JANTAN GALUR WISTAR YANG DIINDUKSI KARBON TETRAKLORIDA

Dewinta Putri Utami, Andriani Andriani, Mardhia Mardhia, Virhan Novianry, Mistika Zakiah

Abstract

Background: Andrographolide is a diterpenoid bioethanol that effectively prevent liver injury by reducing liver oxidative stress response. Method : The research was randomized experimental design with pretest-posttest design. Thirty male wistar rats was randomly divided into 6 groups, normal control, negative control (0,2 ml CCl₄), and positive control (500 mg/kgBW curcumin), dose I (50 mg/kgBW), dose II (100 mg/kgBW), dose III (200 mg/kgBW) given for 8 days and induced by 0,2 ml CCl₄ on the first day. Data was analyzed by One-Way Anova test, LSD Post-Hoc test and paired T test. Results :All groups induced by CCl4 shows elevated of ALT activity. The posttest results shows significant differences of ALT activity between groups (p<0,05). Conclusion : Andrographolide shows hepatoprotector effect by decrease the activity of ALT in male wistar rats induced by CCl₄. The effective dose of andrographolide is 200 mg/kgBW.

Keywords

Andrographolide, CCl4, hepatoprotector, alanine aminotransferase

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DOI: https://doi.org/10.33096/jffi.v8i1.582

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