Potential of  Extract of Tamarindus Indica L Leaves an Anti-Inflammatory on Carrageenan Induced Wistar Rats

Aulia Wati; Sukmawati Sukmawati; Bayu Putra

doi:10.33096/jffi.v10i3.1107

Potential of Extract of Tamarindus Indica L Leaves an Anti-Inflammatory on Carrageenan Induced Wistar Rats

Aulia Wati, Sukmawati Sukmawati, Bayu Putra

Abstract

Tamarind leaves are used in traditional medicine for inflammation, stomach pain, rheumatism, and sore throats. The aims of this study was to determined the potential of extract tamarind leaf as an anti-inflammatory in Wistar rats. This study was used experimental rats divided into 5 groups, namely group I was given Na. CMC, group II was given diclofenac sodium dose of 5.136 mg/kgBW, groups III, IV, and V were given ethanol extract of tamarind leaves at a doses of 250, 500 and 1000 mg/kgBW. The test animals induced with 1% lambda carrageenan by intraplantar after one hour given test preparation orally. Measurements of edema volume and thickness of the rats were carried out before and after induction for 7 hours at 1 hour intervals using a pletysnometer and calipers. The research data was calculated statistically using the one way anova test and Post Hoc LSD. The results of the study showed that the extract group at a dose of 1000 mg/kgBW had an anti-inflammatory effect not significantly different compared to the diclofenac sodium group at a dose of 5.136 mg/kgBW. Therefore, obtained results showed that the extract of tamarind leaf has an anti-inflammatory effect with an effective dose of 1000 mg/kgBW.

Keywords

antiiflamation; Tamarindus indica L; carrageenan

Full Text:

PDF

References

Akor, T.S., Wampana, B.O., Sodipo, A. (2015). Antinociceptive and anti-inflammatory activities ofthe aqueous leaf extract of Tamarindus indica L. in albino rats. JPS:4, http://dx.doi.org/10.5539/jps.v4n2p4

Bhadoriya, S.S., Mishra, V., Raut, S., Ganeshpurkar, A., Jain, K.S. (2012). Anti-inflammatoryand antinociceptive activities of a hydroethanolic extract of Tamarindus indica leaves. Scient Pharmaceut, 80, 685–700.42. https://pubmed.ncbi.nlm.nih.gov/23008815/

Dipiro, J.T et.al. (2020). Pharmacotherapy A Pathophysiologic Approach (11th Ed). United States : by McGraw Hill

Frederickson, N.F and David, M. (2018). Introduction to Immunity and Inflammation cis Brunton, LL., Hilal-Dandan R, Knollman BC. Goodman & Gilman’s, Manual of Pharmacology and Therapeutics (13th Ed). United States. McGraw-Hill Education

Hanani, E. (2015) Analisis Fitokimia, Penerbit Buku Kedokteran EGC, Jakarta, hh. 6-11

Komakech, R., Goo Kim, Y., Matsabisa, GM., Kang, Y. (2019). Anti-inflammatory and analgesic potential of Tamarindus indica Linn. (Fabaceae): a narrative review. Integrative Medicine Research, 8, 181–186

Kowalak, J.P.,Welsh, W., dan Mayer B. (2011) Buku Ajar Patofisiologi, Penerbit Buku Kedokteran EGC, Jakarta, h. 58

Kumar, V., Abbas, A.K., Aster, J.C., Deyrup, A.T. (2021). Robbins Essential Pathology. Philadelphia by Elsevier.

Li, S., Liu, X., Chen, X.R and Bi, L. (2020). Research Progresson Anti-Inflammatory Effects and Mechanisms of Alkaloids from Chinese Medical Herbs. Evidence-Based Complementary and Alternative Medicine, Article ID 1303524, 10 pages https://doi.org/10.1155/2020/1303524

Mun’im, A., Hanani, E., Rahmadiah. (2009). Karakterisasi Ekstrak Etanolik Daun Asam Jawa (Tamarindus indica L). Majalah Ilmu Kesehatan Kefarmasian, Vol.1,Hal. 44

Nijveldt, R.J., Nood, E.V., Hoorn, D.E.C., Boelens P.G., Norren, K.V., dan Leeuwen, P.A.M. (2001). Flavonoids : A Review of probable mechanisms of action and potential application. Am J Clin Nutr., 74,418-425.

Pramana, J.D. (2008). Uji Efek Antiinflamasi Infus Daun Asam Jawa (Tamarindus indica L). Pada Tikus Putih Jantan. Fakultas Farmasi. Universitas Katolik Widya Mandala. Surabaya

Pramitaningastuti, A.S., Anggraeny, A.N. (2017). Uji Efektivitas Antiinflamasi Ekstrak Etanol Daun Srikaya (Annona squamosa. L) Terhadap Udema Kaki Tikus Putih Jantan Galur Wistar. Jurnal Ilmiah Farmasi, 13(1), 8-13 ISSN: 1693-8666, http://journal.uii.ac.id/index.php/JIF

Samodra, G., Febrina D.(2019). Anti-Inflammatory Effects of Kaempferia galanga L. Rhizome Extract in Carrageenan-Induced Female Rats. Advances in Health Sciences Research, 20, 1-27.

Singh, S., Kaur, M., Singh, A and Kumar, B. (2014). Pharmacological Evaluation of Anti-Inflammatory and Anti-Ulcer Potential of Heartwood of Santalum Album in Rats, Asian Journal of Biochemical and Pharmaceutical Research, 1(4), ISSN: 2231-2560, 140-153, Researchgate.net/publication/264166755_Pharmacological_Evaluation_of_Anti-Inflammatory_and_AntiUlcer_Potential_of_Heartwood_of_Santalum_Album_in_Rats/link/53d0e76d0cf25dc05cfe70fa/download

Sutrisna, E.M., Widyasari, D.F., dan Suprapto. (2010). Uji efek anti inflamasi ekstrak etil asetat buah semu jambu mete (Anacardium occidentale L.) terhadap udema pada telapak kaki tikus putih (Rattus norvegicus) jantan yang diinduksi karagenan. Biomedika, 2(1), 33-37.

Wijesinghe, W., Ahn, G., Lee, W.W., Kang, M.C., Kim, E.A., Jeon, Y.J. (2013). Anti-inflammatory activity of phlorotannin-rich fermented Ecklonia cava processing by-product extract in lipopolysaccharide stimulated RAW 264.7 macrophages. J Appl Phycol. 25:1207–13. doi: 10.1007/s10811-012-9939-5

Winter, C.A., Risley, E.A., and Nuss, G.W. (1962). Carrageenan induced oedema in hind paw of the rats as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Bio Med, 111, (544-547).

DOI: https://doi.org/10.33096/jffi.v10i3.1107

Copyright (c) 2023 Aulia Wati, Sukmawati Sukmawati, Bayu Putra