https://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/issue/feedAs-Syifaa Jurnal Farmasi2023-12-11T10:09:48+09:00Editorial As-Syifaa: Jurnal Farmasijurnal.farmasi@umi.ac.idOpen Journal Systems<span>Jurnal Ilmiah Farmasi As-Syifaa merupakan jurnal yang dikelola dan diterbitkan oleh Fakultas Farmasi Universitas Muslim Indonesia Makassar dengan maksud untuk mempublikasikan hasil-hasil penelitian yang telah dilakukan oleh dosen, baik dosen tetap UMI maupun dosen dari perguruan tinggi lain dalam bidang farmasi.</span>https://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/article/view/1077SAMPUL AS-SYIFAA JURNAL FARMASI 15.2 (2023)2023-12-11T10:07:16+09:00SAMPUL 15.2 (2023)jurnal.farmasi@umi.ac.id2023-12-01T00:00:00+09:00Copyright (c) 2023 As-Syifaa Jurnal Farmasihttps://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/article/view/1078DAFTAR ISI AS-SYIFAA JURNAL FARMASI 15.2 (2023)2023-12-11T10:09:48+09:00DAFTAR ISIjurnal.farmasi@umi.ac.id2023-12-01T00:00:00+09:00Copyright (c) 2023 As-Syifaa Jurnal Farmasihttps://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/article/view/1032PENGARUH INTERVENSI EDUKASI BERBASIS APLIKASI PONSEL PINTAR TERHADAP TINGKAT KUALITAS HIDUP PENDERITA DIABETES MELITUS TIPE 22023-12-11T09:58:29+09:00Ameirzan Maulana Juhaeniameirzan.m.fkik19@mail.umy.ac.idMuhammad Thesa Ghozalighozali@umy.ac.id<em>Poor quality of life is one of the leading causes of death in individuals with diabetes mellitus, so people with diabetes need to be educated about the disease to have a decent quality of life and avoid complications. Today's technological advances have resulted in the emergence of many new innovations, including in the health sector, such as the use of smartphone apps for patient education. This study seeks to describe the quality of life of type 2 diabetes mellitus patients in the outpatient installation at PKU Muhammadiyah Gamping Hospital and to ascertain whether there are any differences between the quality of life of these patientss' prior to and following the administration of educational interventions based on smartphone applications. This study falls under the category of pre-experimental research, with a one-group pretest and posttest design. Respondents for this study were recruited using the quota sampling approach, which yielded up to 50 participants based on the research requirements. This study was conducted at the PKU Muhammadiyah Gamping Hospital outpatient facility from October to December 2022. The Diabetes Quality of Life (DQoL) questionnaire was used to collect research data before and after the smartphone application-based educational intervention "Diary Diabetes" was given to respondents. According to the findings of this study's descriptive statistical analysis, out of 50 respondents, 37 (or 74%) had high levels of life satisfaction. The study's findings also revealed an increase in the average, median, maximum, and standard deviation of the respondents. According to the hypothesis test, the study's paired sample t- test had a significance value of 0.003, indicating that there was a difference between the patients' quality of life before and after receiving smartphone application-based educational interventions for type 2 diabetes mellitus in the outpatient facility of PKU Muhammadiyah Gamping Hospital</em><p> </p>2023-12-01T10:37:24+09:00Copyright (c) 2023 As-Syifaa Jurnal Farmasihttps://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/article/view/1031ANALISIS BAHAN KIMIA OBAT NATRIUM DIKLOFENAK DALAM SEDIAAN JAMU ASAM URAT YANG BEREDAR DI KOTA TIMIKA2023-12-11T09:58:29+09:00St. Maryamst.maryam@umi.ac.idAsriani Suhaenahasriani.suhaenah@umi.ac.idRusniyanti Rusniyantirusniyanti13@gmail.com<em>Uric acid herbs are an alternative that is still widely used by the community as an anti-inflammatory and pain reliever. The increasing public interest in returning to traditional medicine has prompted several manufacturers to add medicinal chemicals to their preparations to produce a faster and maximum therapeutic effect, one of which is diclofenac sodium. The study aimed to analyze the chemical ingredients of the uric acid herbs circulating in Timika City and to find out the level of diclofenac sodium contained therein. The method used is High Performance Liquid Chromatography (HPLC) with reverse phase, where the mobile phase is methanol: aquabidestilata (80:20) and the stationary phase is column C-18. Based on the test results, nine uric acid herbs showed positive results with retention times at the same value as diclofenac sodium. The content of diclofenac sodium obtained were code A herb of 4.135 mg/L, B herb : 36.300 mg/L, C herb : 18.530 mg/L, herb D : 473.219 mg/L, herb E : 40.991 mg/L, herb F : 77.165 mg/L L, herb G : 93.109 mg/L, herb H : 52.700 mg/L, and herb I : 297.123 mg/L. All herb samples tested were unfit for public use because they contained the chemical drug sodium diclofenac</em>2023-12-01T10:37:25+09:00Copyright (c) 2023 As-Syifaa Jurnal Farmasihttps://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/article/view/975UJI EFEK KOMBINASI EKSTRAK DAUN ALPUKAT (Persea americana Mill.) DAN DAUN SRIKAYA (Annona squamosa L.) SEBAGAI ANTIOBESITAS PADA TIKUS JANTAN2023-12-11T09:58:29+09:00Aulia Watiaulia.wati@umi.ac.idIra Asmalianiira.asmaliani@umi.ac.idHendra Hermanhendra.herman@umi.ac.idAlfiah Fira15020190223@umi.ac.id<p><em>Obesity is a condition where there is a buildup of excess body fat so that a person's weight is far above normal. This study aims to determine the effectiveness of the combination of avocado leaf extract (<span style="text-decoration: underline;">Persea americana</span> Mill. ) and srikaya leaves (<span style="text-decoration: underline;">Annona squamosa</span> L.) as antiobesity in male rats. This study used 18 mice. Rats were given high-fat carbohydrate feed as much as 25 grams a day for 28 days to get obese conditions, followed by oral trial preparation therapy for 14 days with dose variations, namely group I (negative control), group II (positive control), group III avocado leaf extract 60 mg / kg BB, group IV srikaya leaf extract 125 mg / kg BB, group V extract combination small dose avocado leaf extract 60 mg/kgBB and srikaya leaf 125 mg/kgBB, and group VI extract combination large dose avocado leaf extract 120 mg/kgBB and srikaya leaf extract 250 mg/kgBB. Measurement of the Lee index of test animals was carried out before induction, after induction and after therapy then continued with surgery to determine the weight of perianal, perirenal, and peritonial fat. The results showed that a combination extract of small doses of avocado leaves 60 mg/kgBB and srikaya leaves 125 mg/kgBB had the most effective effect compared to other treatment groups</em></p>2023-12-01T10:37:25+09:00Copyright (c) 2023 As-Syifaa Jurnal Farmasihttps://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/article/view/1054UJI TOKSISITAS SUBKRONIS EKSTRAK ETANOL DAUN MENGKUDU (Morinda citrifolia L.) DENGAN PENETAPAN KADAR KREATININ DAN BUN TIKUS PUTIH2023-12-11T09:58:29+09:00Farikha Rahmatudinafarikhadhina@gmail.comReslely Harjantireslely.nindy@gmail.comJena Hayu Widyastijenahayu89@gmail.com<p><em>The subchronic toxicity test of Noni (<span style="text-decoration: underline;">Morinda citrifolia</span> L.) ethanol leaf extract have been studied. The purpose of this study was to determine the effect of subchronic toxicity of noni ethanol leaf extract (<span style="text-decoration: underline;">Morinda citrifolia</span> L.) on increased levels of creatinine and BUN (Blood Urea Nitrogen) of white rats. Noni leaves were extracted by using the maceration method with 96% ethanol dissolution for 3 times 24 hours while occasionally stirring until a thick extract was obtained. Then the blood creatinine and BUN levels were determined before administering the test preparation and on day 28. The research was carried out for 28 days then continued for 14 days for the satellite group. The results of the subchronic toxicity testing that was carried out showed a double increase in creatinine and BUN levels compared to normal values. Noni leaf extract treatment caused an increase in creatinine and BUN levels in the subchronic toxicity test at doses of 250, 500 and 1000 mg/kg BW, and the highest increase in levels occurred in the 1000 mg/kg BW group</em></p>2023-12-01T10:37:26+09:00Copyright (c) 2023 As-Syifaa Jurnal Farmasihttps://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/article/view/1055EFEK ANALGETIK EKSTRAK AKUADES DAUN MELINJO (Gnetum gnemon L.) PADA MENCIT PUTIH (Mus musculus L.) JANTAN DENGAN METODE INDUKSI ASAM ASETAT 1%2023-12-11T09:58:29+09:00Evelyne Citra Dewievelynecitradewi01@gmail.comAnwar Sodikanwarsodik@unimugo.ac.idHusnul Khuluqhusnulkhuluq@unimugo.ac.idRafila Intiyanirafila_intiyani@unimugo.ac.id<em>Pain is an unpleasant sensory and emotional feeling, associated with tissue damage. Melinjo leaves (<span style="text-decoration: underline;">Gnetum gnemon</span> L.) are a plant that is useful as a traditional medicine for reducing and treating diseases, one of which is pain. The use of traditional medicine has fewer side effects than chemical medicine. This study aims to determine the analgesic activity and best dose of melinjo leaf distilled water extract in male white mice induced by 1% acetic acid. This research is experimental research. The subjects of this research were 25 male white mice. Mice were divided into 5 treatment groups with each group consisting of 5 mice. The treatment groups consisted of negative control CMC-Na 1%, positive control, melinjo leaf aqueous extract group at doses of 50, 100, and 150 mg/kgBW. The pain inducer was given 1% acetic acid. Observations were made by observing the movements of mice to calculate the % of analgesic protection. The data that has been obtained is then tested using One Way Anova and Post Hoc LSD or Games-Howell statistical tests. The results obtained by melinjo leaf aqueous extract at a dose of 150 mg/kgBW had the best analgesic effect because it had the largest % protection, namely 66.89%, and provided a significant effect (p<0.05) in mice induced by 1% acetic acid. Melinjo leaf aqueous extract at a dose of 150 mg/kgBW had the best analgesic effect on male white mice which was declared significant (p<0.05) and the mean difference value was greater.</em>2023-12-01T10:37:26+09:00Copyright (c) 2023 As-Syifaa Jurnal Farmasihttps://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/article/view/1067PENGARUH SUHU PENYIMPANAN TERHADAP SIFAT FISIK TABLET EFFERVESCENT EKSTRAK KULIT BUAH NAGA MERAH (Hylocereus polyrhizus) DAN BUAH LEMON (Citrus limon L.)2023-12-11T09:58:29+09:00Areta Thea Zafirazafiraaretathea@gmail.comTya Muldiyanatya.muldiyana@gmail.comJoko Santosozafiraaretathea@gmail.com<p><em>Effervescent tablet is a dosage form that can produce bubbles originating from an acid and base reaction that forms a gas. The reaction between acids and bases in effervescent tablets is very sensitive to temperature if stored continuously. So that testing for drug stability is very important in evaluating drugs, one of which is by knowing the effect of temperature on drug stability, especially in the form of effervescent tablets. This study aims to determine the effect of storage temperature on the physical properties of effervescent tablets made from red dragon fruit peel extract (<span style="text-decoration: underline;">Hylocereus polyrhizus</span>) combined with lemon fruit powder (<span style="text-decoration: underline;">Citrus limon</span> L.). The research method was carried out by storing effervescent tablets at cold temperature (±12<sup>0</sup>C), room temperature (±25<sup>0</sup>C), and warm temperature (±40<sup>0</sup>C). And observed for 1 month with testing every 1 week. The results of this study are storage temperature can affect the physical properties of effervescent tablets made from red dragon fruit peel extract (<span style="text-decoration: underline;">Hylocereus polyrhizus</span>) with a combination of lemon fruit powder (<span style="text-decoration: underline;">Citrus limon</span> L.). The best temperature is cold temperature around 12<sup>0</sup>C because at that temperature the acid and base reactions in effervescent tablets are not excessive which results in effervescent tablets still in a stable condition</em></p>2023-12-01T10:37:26+09:00Copyright (c) 2023 As-Syifaa Jurnal Farmasihttps://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/article/view/1066POTENSI EKSTRAK ETANOL BATANG WOLE WOE ASAL KABUPATEN HALMAHERA TENGAH SEBAGAI ANTIBAKTERI MENGGUNAKAN METODE KLT-BIOAUTOGRAFI2023-12-11T09:58:29+09:00Fitriana Fitrianafitriana.fitriana@umi.ac.idSitti Amirahsitti.amirah@umi.ac.idSafriani Rahmansafriani.rahman@umi.ac.idRusli Ruslirusli@umi.ac.idAyyub Harly Nurungayyub.harlynurung@umi.ac.id<em>The development of natural materials both from plants and from other materials as traditional medicines can be done by taking habits from the community in utilizing natural materials empirically. The wole woe plant is one of the plants that comes from the forest and grows wildly and is empirically used as a traditional medicine by the Weda community in Central Halmahera Regency. This study aims to see the chromatogram of wole woe stem extract and the group of chemical components that have potential as antibacterial using KLT-Bioautography method. The results of the chromatogram of the ethanol extract of wole woe stem, obtained 6 spots and there are 2 spots with rf values of 0.65 and 0.09 which have activity against bacteria <span style="text-decoration: underline;">Staphylococcus aureus</span>, <span style="text-decoration: underline;">Streptococcus mutans</span>, <span style="text-decoration: underline;">Bacillus subtilis</span> and <span style="text-decoration: underline;">Pseudomonas aeruginosa</span>. The results of the identification of chemical components using specific reagents, obtained chemical groups of anthraquinones, flavonoids, phenolics and alkaloids have potential as antibacterial, so that the ethanol extract of wole woe stem has potential as antibacterial.</em>2023-12-01T00:00:00+09:00Copyright (c) 2023 As-Syifaa Jurnal Farmasihttps://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/article/view/1041FORMULASI DAN EVALUASI SIFAT FISIK DARI SEDIAAN FACE WASH YANG MENGANDUNG EKSTRAK AIR BUNGA KESUMBA TURATE (Carthamus tinctorius L).2023-12-11T09:58:29+09:00Nurhafizah Hamka15020190179@umi.ac.idAndi Hasrawatiandi.hasrawati@umi.ac.idIskandar Zulkarnainiskandar.zulkarnain@umi.ac.idMirawati Mirawatimirawati.mirawati@umi.ac.id<em><span style="text-decoration: underline;">Carthamus tinctorius</span> L. has antioxidant activity and contains polyphenols and flavonoids so it can be used for skin care such as face wash. The aim of this research is to formulate and evaluate a face wash preparation from water extract of <span style="text-decoration: underline;">Carthamus tinctorius</span> L flowers that is physically stable. <span style="text-decoration: underline;">Carthamus tinctorius</span> L water extract face wash preparations have been made in 4 formulas with different gelling agent variations, namely Carbopol and HPMC with concentrations of 1% and 1.5%. Preparation tests that have been carried out include organoleptic tests, homogeneity tests, pH tests, syneresis tests, viscosity tests, flow properties and stability tests. Research results have shown that <span style="text-decoration: underline;">Carthamus tinctorius</span> L water extract can be made into a face wash preparation with a thick consistency, odorless and brown in color. The preparation that has been made is homogeneous and has a pH between 3-6. The viscosity ranges from 30.4 – 159.8 P with a plastic flow type with a yield value between 13.5 – 32.9 dyne/cm2. Syneresis tests have shown water loss between 7.13 – 19.7%. The results of the stability test have shown that the formula with gelling agent HPMC at a concentration of 1.5% has pharmaceutical properties that do not change after stress conditions.</em>2023-12-01T00:00:00+09:00Copyright (c) 2023 As-Syifaa Jurnal Farmasihttps://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/article/view/991UJI EFEK ANTIDIARE EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R Forst & G. Forst) PADA TIKUS PUTIH JANTAN (Rattus novergicus)2023-12-11T09:58:29+09:00Irma Santiirma.santi@umi.ac.idBayu Putrabayu.putra@umi.ac.idRachmat Kosmanrachmatkosman@umi.ac.idFitrah Anggun Ramadhaniirma.santi@umi.ac.idHativa Hativairma.santi@umi.ac.id<em>Diarrhea is a condition where defecation with a frequency of more than 3 times a day and the consistency of liquid or semi-liquid feces with water content that exceeds normal limits. One plant that is thought to have antidiarrheal effects with tannin content in it is matoa leaves (<span style="text-decoration: underline;">Pometia pinnata</span> J.R Forst &; G. Forst). This study was conducted experimentally using 25 male white rats induced castor oil (<span style="text-decoration: underline;">Oleum ricini</span>) as a laxative. After being induced, experimental animals were divided into 5 groups, namely the negative control group (NaCMC), the positive control group (Loperamid), the the ethanol extract of matoa leaves group with doses of 200 mg/KgBB, 400 mg/KgBB, 800 mg/KgBB. All treatments were carried out orally. Then observed the frequency of diarrhea and the consistency of feces every 30 minutes for 5 hours. Furthermore, the results of the study were analyzed statistically using the Kruskal Wallis test then continued with the Post Hoc LSD test. From the results of the study it can be concluded that the ethanol extract of matoa leaves has an antidiarrheal effect on male white rats induced castor oil with an effective dose of 800 mg/KgBB</em>2023-12-05T00:00:00+09:00Copyright (c) 2023 As-Syifaa Jurnal Farmasihttps://jurnal.farmasi.umi.ac.id/index.php/as-syifaa/article/view/1069AKTIVITAS ANTIBAKTERI ISOLAT FUNGI ENDOFIT BIJI LABU KUNING (Cucurbita moschata ex. Poir)2023-12-11T09:58:29+09:00Siska Nuryantisiska.nuryanti@umi.ac.idFitriana Fitrianafitriana.fitriana@umi.ac.idFitriah Anggraini Ohorellasiska.nuryanti@umi.ac.id<em><span style="text-decoration: underline;">Cucurbita moschata</span> ex. Poir are one of the medicinal plants that have many benefits, including antidiabetic, antifungal, antibacterial, anti-inflammatory, and antioxidant effects. The content of compounds in yellow pumpkin seeds, such as phenols, alkaloids, and triterpenoids, This study aims to isolate endophytic fungi from yellow pumpkin seeds and test the antibacterial activity of isolates of yellow pumpkin bii endophytic fungi using the Agar diffusion method. The results of the isolation of yellow pumpkin seed endophytic fungi obtained 3 isolates, followed by macroscopic examination and fermentation of the 3 isolates with Maltose Yeast Broth (MYB) media and testing antibacterial activity by Agar diffusion method. Based on the results of the study, 3 isolates with the codes IJBL1, IJBL2, and IJBL3 were obtained that have antibacterial potential. The highest inhibitory zone was produced by IJBL3 endophytic fungi isolate with an inhibitory zone diameter of 12.39 mm against <span style="text-decoration: underline;">Staphylococcus aureus</span> bacteria</em>2023-12-11T00:00:00+09:00Copyright (c) 2023 As-Syifaa Jurnal Farmasi