PENGARUH PEMBERIAN EKSTRAK DAUN BIDARA (Zizipus mauritiana Lam.) TERHADAP FUNGSI HATI TIKUS DENGAN PARAMETER SGPT
DOI:
https://doi.org/10.56711/jifa.v16i1.1127Keywords:
Liver, SGPT, Toxicity, Zizhiphus mauritiana L.Abstract
Repeated administration of traditional medicines can be potentially poisonous and damage vital organs such as the heart, lungs, liver and kidneys. Tests of safety need to be carried out. Bidara leaves are used traditionally used as antimicrobial, analgesic, antipyretic, anti-inflammatory, anti-diabetic. This study aims to determine safety of ethanol extract of bidara leaves on liver function. This research used wistar rats as test animals which were divided into 4 groups. Test animals were given ethanol extract of bidara leaves at a dose of 50 mg/kgBW, 500 mg/kgBW and 2000 mg/kgBW given orally for 14 days. SGPT rate checks are carried out before and after administering the extract. The results showed that giving ethanol extract of bidara leaves for 14 days did not have a significant effect on rat SGPT levels (p<0.05).
References
Wasito H. Meningkatkan Peran Perguruan Tinggi Melalui Pengembangan Obat Tradisional. MIMBAR : Jurnal Sosial dan Pembangunan. 2008; 24(2):117–128
Alydrus LN, Gama SI, Rijai L. Skrining Fitokimia Dan Uji Aktivitas Antibakteri Ekstrak Daun Bidara (Ziziphus mauritiana) Terhadap Bakteri Propionibacterium acnes. Proceeding of Mulawarman Pharmaceuticals Conferences. 2023; 17:38–43
Blegur F, Korasa YB, Makoil SD. Antioxidant Activities of Herbal Drinks of Bidara (Zizyphus mauritiana Lamk) Leaves with Variation of Boiling Time Using DPPH Method (1,1-Diphenyl-2- Picryhydrazyl). In: 1st International Conference Health Polytechnic Of Ministry Of Health Kupang, pp. 483–490
Plastina P et al. Identification of Bioactive Constituents of Ziziphus jujube Fruit Extracts Exerting Antiproliferative and Apoptotic Effects in Human Breast Cancer Cells. J Ethnopharmacol. 2012; 140(2):325–332
Gaur A, Sharma GN. Ziziphus mauritiana Lam-an Overview. Indo American Journal of Pharm Research. 2013; 3(6):4560–4566
Elya B, Amin J, Emiyanah. Toksisitas Akut Daun Justicia gendarussa Burm. Makara J Sci. 2010; 14(2):129–134
PERBPOM. Peraturan Badan Pengawas Obat Dan Makanan Nomor 10 Tahun 2022 Tentang Pedoman Uji Toksisitas Praklinik Secara In Vivo. Jakarta. 2022
Muharni M et al. Uji Toksisitas Subkronik Ekstrak Etanol Daun Sungkai (Paronema canescens Jack.) Terhadap Tikus Putih Rattus novergicus (Wistar Strain). JSFK (Jurnal Sains Farmasi & Klinis). 2023; 10(2):211–217
Dhuha NS, Haeria, Putri HE. Toksisitas Akut Ekstrak Etanol Daun Bidara (Ziziphus spina-christi L.) Berdasarkan Gambaran Morfologi Dan Histologi Hati Mencit. Ad-Dawaa’ Journal of Pharmaceutical Sciences. 2019; 2(1):43–48
Widarti W, Nurqaidah N. Analisis Kadar Serum Glutamic Pyruvic Transaminase (SGPT) Dan Serum Glutamic Oxaloacetic Transaminase (SGOT) Pada Petani Yang Menggunakan Pestisida. Jurnal Media Analis Kesehatan. 2019; 10(1):35–43
Tanoeisan AP, Mewo YM, Kaligis SHM. Gambaran Kadar Serum Glutamic Pyruvic Transaminase (SGPT) Pada Perokok Aktif Usia > 40 Tahun. eBiomedik.; 4(1). DOI: 10.35790/EBM.V4I1.11048
Depkes RI. Analisis Obat Tradisional. . Jakarta: Depkes RI. 1987
Lallo S et al. Aktivitas Anti Inflamasi Dan Penyembuhan Luka Dari Ekstrak Kulit Batang Murbei (Morus alba L.). Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal). 2020; 6(1):26–36
Sari HK, Budirahardjo R, Sulistyani E. Kadar Serum Glutamat Piruvat Transaminase (SGPT) Pada Tikus Wistar (Rattus norvegicus) Jantan Yang Dipapar Stresor Rasa Sakit Berupa Electrical Foot Shock Selama 28 Hari. Pustaka Kesehatan. 2015; 3(2):205–211
Yuliawati Y, Putri WCW, Rahman H. Uji Aktivitas Hepatoprotektor Ekstrak Etanol Daun Rambutan (Nephelium lappaceum L.) Pada Mencit Putih Jantan Yang Diinduksi Parasetamol. Pharmacon: Jurnal Farmasi Indonesia. 2021; 18(2):148–156
Hasan H et al. Skrining Fitokimia Dan Uji Aktivitas Antioksidan Kulit Batang Matoa (Pometia pinnata) Dengan Metode 1,1-Diphenyl-2 Picrylhidrazyl (DPPH). Indonesian Journal of Pharmaceutical Education. 2022; 2(1):67–73
