UJI EFEK ANTIDIARE EKSTRAK ETANOL DAUN MATOA (Pometia pinnata J.R Forst & G. Forst) PADA TIKUS PUTIH JANTAN (Rattus novergicus)

Irma Santi, Bayu Putra, Rachmat Kosman, Fitrah Anggun Ramadhani, Hativa Hativa

Abstract


Diarrhea is a condition where defecation with a frequency of more than 3 times a day and the consistency of liquid or semi-liquid feces with water content that exceeds normal limits. One plant that is thought to have antidiarrheal effects with tannin content in it is matoa leaves (Pometia pinnata J.R Forst &; G. Forst). This study was conducted experimentally using 25 male white rats induced castor oil (Oleum ricini) as a laxative. After being induced, experimental animals were divided into 5 groups, namely the negative control group (NaCMC), the positive control group (Loperamid), the the ethanol extract of matoa leaves group with doses of 200 mg/KgBB, 400 mg/KgBB, 800 mg/KgBB. All treatments were carried out orally. Then observed the frequency of diarrhea and the consistency of feces every 30 minutes for 5 hours. Furthermore, the results of the study were analyzed statistically using the Kruskal Wallis test then continued with the Post Hoc LSD test. From the results of the study it can be concluded that the ethanol extract of matoa leaves has an antidiarrheal effect on male white rats induced castor oil with an effective dose of 800 mg/KgBB

Keywords


Castor Oil; Diarrhea; Ethanol Extract; Matoa Leaf

References


Setiati S et al. Buku Ajar Ilmu Penyakit Dalam. 6 Jilid 2. Jakarta: Interna Publishing. 2014

Melvani RP, Zulkifli H, Faizal M. Analisis Faktor Yang Berhubungan Dengan Kejadian Diare Balita di Kelurahan Karyajaya Kota Palembang. Jumantik (Jurnal Ilmiah Penelitian Kesehatan). 2019; 4(1):57–68

WHO. World Health Day 2013: Measure Your Blood Pressure, Reduce Your Risk, URL: Https://Www.Who.Int/News/Item/03-04-2013-World-Health-Day-2013-Measure-Your-Blood-Pressure-Reduce-Your-Risk. https://www.who.int/

Diarrhoeal Disease, URL: https://www.who.int/news-room/fact-sheets/detail/diarrhoeal-disease. (accessed 27 November 2023)

Nurhalimah H, Wijayanti N, Widyaningsih TD. Efek Antidiare Ekstrak Daun Beluntas (Pluchea indica L.) Terhadap Mencit Jantan Yang Diinduksi Bakteri Salmonella thypimurium [IN PRESS JULI 2015]. Jurnal Pangan dan Agroindustri. 2015; 3(3):1083–1094

Trimedona N, Nurdin H, Darwis D, Efdi M. Isolation of Triterpenoid from Stem Bark of Pometia pinnata, Forst & Forst. J Chem Pharm Res. 2015; 7(11):225–227

Irawan C, Hanafi H, Sulistiawaty L, Rochaeni H. Phytochemistry and Total Phenolic Content of Methanol Extract of Pometia pinata J.R. Forst. & G. Forst. Fruit Flesh from Papua, Indonesia. Tropical Plant Research. 2017; 4(3):401–404

Martiningsih NW, Widana GAB, Kristiyanti PLP. Skrining Fitokimia dan Uji Aktivitas Antioksidan Ekstrak Etanol Daun Matoa (Pometia pinnata) dengan Metode DPPH. Prosiding Seminar Nasional MIPA. 2016; :332–338

Kuspradini H, Pasedan WF, Kusuma IW. Aktivitas Antioksidan dan Antibakteri Ekstrak Daun Pometia pinnata. Jurnal Jamu Indonesia. 2016; 1(1):26–34

Sani F. Efektivitas Ekstrak Daun Remek Daging (Hemagraphis colorata Hall F.) Sebagai Antidiare Pada Mencit Jantan. Borneo Journal of Pharmascientech. 2017; 1(1):18–27

Nofita D, Dewangga R. Optimasi Perbandingan Pelarut Etanol Air Terhadap Kadar Tanin Pada Daun Matoa (Pometia pinnata J.R & G. Forst) Secara Spektrofotometri. Chimica et Natura Acta. 2021; 9(3):102–106

Prasetyo, Inoriah E. Pengelolaan Budidaya Tanaman Obat-Obatan (Bahan Simplisia). Bengkulu: Badan Penerbitan Fakultas Pertanian UNIB. 2013

Keswara YD, Handayani SR. Uji Aktivitas Analgetik Ekstrak Etanol Daun Inggu (Ruta angustifolia [L.] Pers) Pada Tikus Putih Jantan. Journal Syifa Sciences and Clinical Research. 2019; 1(2):57–69

Santi I, Putra B, Rahman FU. Analgesic Effect Test of Matoa Leaf Ethanol Extract (Pometia pinnata J.R. Forst & G. Forst) in Male White Mice (Mus musculus). Journal Borneo. 2023; 3(2):72–79

Manek MS, Klau ME, Beama CA. Uji Aktivitas Antidiare Ekstrak Etanol Daun Sirih (Piper betle L.) Pada Tikus Putih Jantan Galur Wistar Yang Diinduksi Oleum ricini . CHMK Pharmaceutical Scientific Journal. 2020; 3(2):147–151

Puspitaningrum I, Wahyu A, Suwarmi. Uji Anti Diare Infusa Daun Mimba (Azadirachta indica Juss) Terhadap Mencit Jantan Galur Swiss. Media Farmasi Indonesia. 2013; 8(2):596–599

Adrianto A, Santoso J, Suprasetya E. Uji Effektivitas Antidiare Ekstrak Etanol Daun Bidara (Ziziphus maurtiana Lam. ) Pada Mencit Jantan ( Mus musculus ) Dengan Induksi Oleum ricini. Jurnal Permata Indonesia. 2017; 8(2):59–74

Sukmawati IK, Sukandar EY, Kurniati NF. Aktivitas Antidiare Ekstrak Etanol Daun Suji (Dracaena angustifolia Roxb). Pharmacy: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia). 2018; 14(2):173–187




DOI: https://doi.org/10.56711/jifa.v15i2.991

Refbacks

  • There are currently no refbacks.


Indexed by:

     

ISSN: 2085-4714 | e-ISSN: 2502-9444

Editor's Address:

Faculty of Pharmacy, Univeristas Muslim Indonesia
2nd Campus of UMI: Jl. Urip Sumoharjo km. 5 , Makassar, South Sulawesi, Indonesia

E-mail: jurnal.farmasi@umi.ac.id

View My Stats