UJI AKTIVITAS GEL LENDIR BEKICOT (Achatina fulica) SEBAGAI PENYEMBUHAN LUKA SAYAT

Fenita Shoviantari, Shofiatul Fajriyah, Ela Agustin, Shafia Khairani

Abstract


Snail mucus (Achatina fulica) has a high protein content, which includes beta agglutinin, achasin protein, acharan sulfate, and glycoconjugate. The objectives of this study was to determine differences in physical evaluation of the quality of the gel preparation against snail mucus concentration and to determine the efficacy of snail mucus gel as a wound healing. This study used an experimental research method with a sample of 4 male rats (Rattus novergicus) which were divided into 6 groups in each. The results showed that there was no effect of the physical quality of snail slime gel (Achatina fulica) on the concentration of snail slime formulated. It has been proven in the Kruskall wallis statistical test with the Sig. > 0.05. The results of the wound healing activity test showed an average value of K (+) 49.61%, K (-) 17.48%, P1 48.23%, P2 43.63%, P3 43.43%, and P4 23, 97. Values that indicate differences in K (-) and P4 are evidenced in the Post Hoc LSD test with Sig. <0.05. It can be concluded that the concentration of snail mucus does not affect the physical quality of snail mucus gel preparations and snail mucus gel with snail mucus concentration of 10% is effective in the process of wound healing.

Keywords


Rat, wound, healing, gel, mucus.

References


Mescher AL. Histologi Dasar Junqueira: Teks dan Atlas. Ed(12). Alih bahasa, Frans Dani. Jakarta:EGC, 2011.

Berman S. Buku Ajar Praktik Keperawatan Klinis. Jakarta:EGC, 2009.

Thomas S. Surgical Dressing and Wound Management. South Wales: Metedec Publications, 2010.

Guo D. Factors Affecting Wound Healing. Critical Review in Oral Biology And Medicine 2010. 89(3):2019-229.

Udofia GA. Formulation of The Mixed- Integer GoalProgram-ming Model For Flour Producting Componies. Asian Journal of Mathematics and Statistics 2009, Vol:2(3):55-64.

Ali. Uji Komparasi Cepat Penyembuhan Luka Bersih pada Kelinci Antara Pemberian Larutan Povidone iodine 10% dan Lendir Bekicot (Achatina fulica) (Skripsi). Yogyakarta, 2009

Harti AS. The Effectiveness of Snail Mucus (Achatina fulica) and Chitosan Toward Limfosit Proliferation In Vitro. Asian Journal of Pharmaceutical and Clinical Research 2018. Vol:11(3).

Putra MA. Effektifitas Pemberian Lendir Bekicot (Achatina fulica) dan Sediaan Krim 5% Terhadap Lama Penyembuhan Luka Bakar Secara Invivo. Indonesian Nursing Student Journal 2015, Vol.3(1):52-63.

Rowe RC. Handbook of Pharmaceutical Excipients. Six Edition. American Pharmacists Association: Pharmaceutical Press, 2009.

Mardiana, Amila, Lanny. Formulasi Gel yang Mengandung Lendir Bekicot (Achatina fulica) Serta Uji Aktivitas Antibakteri Terhadap Propionibacterium acne. UNISBA 2015, pp223-224

Auterhoff K. Identifikasi Obat. Bandung: ITB, 2002

Syamsuni. Farmasetika Dasar Dan Hitungan Farmasi. Jakarta: EGC, 2005.

Rawlins EA. Bentleys of Pharmaceutics. 18 th. London: Baillierre Tindal, 2003.

Maulina. Formulasi Gel Ekstrak Etanol Kulit Buah Manggis (Garcinia mangostana L.) Dengan Variasi Gelling Agent Sebagai Sediaan Luka Bakar. Pharmaciana, 2015; 5(1):43-52.

Kumar R. Buku Ajar Patologi. V(2). Ed(7). EGC:Jakarta, 2011.

Naibaho. Pengaruh Basis Salep Terhadap Formulasi Sediaan Salep Ekstrak Daun Kemangi (Ocinum sanchum L.) pada Kulit Punggung Kelinci yang dibuat Infeksi Staphylococcus aureus. Jurnal ilmiah Farmasi UNSRAT 2013, Vol.2(2).

Nevi S. Formulasi Sabun Transparan Minyak Nilam Sebagai Obat Jerawat. Jakarta: UHAMKA, 2006.

Yati K, Mahdi J, Misri Y, Mardiastuti, Lusi. Pengaruh Konsentrasi HPMC sterhadap Stabilitas Fisik Ekstrak Tembakau dan Aktivitas terhadap Streptococcus mutans. Pharmaceutical Sciences and Research, 2018:5(3):133-141.

Anggraeni, Sri, Endang TWM. Profil Protein dan Daya Anti Mikroba Lendir Bekicot (Achatina fulica) Terhadap MRSA.Surakarta, 2018.

Jeong JA. Localization and Characterization of Acharan Sulfate in the Body of the Giant African Snail Achatina fulica Comp. Biochem Physiol,2001; 30:513-519.

Suriadi. Perawatan Luka. Jakarta: Sagung seto, 2004.




DOI: https://doi.org/10.56711/jifa.v13i1.761

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ISSN: 2085-4714 | e-ISSN: 2502-9444

Editor's Address:

Faculty of Pharmacy, Univeristas Muslim Indonesia
2nd Campus of UMI: Jl. Urip Sumoharjo km. 5 , Makassar, South Sulawesi, Indonesia

E-mail: jurnal.farmasi@umi.ac.id

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