AKTIVITAS ANTIFUNGI TEMU PUTIH (Curcuma zedoaria) TERHADAP Trichophyton mentagrophytes

Siska Nuryanti

Abstract


Curcuma zedoaria has long been known to be used in treatment of dermatophytosis; a skin disease caused by dermatophytes fungi such as Trichophyton mentagrophytes.The fungi infects hairs, skins, and nails that contain keratin. The study was conducted in order to measure the effect of ethanol extract of curcuma zedoaria in inhibiting Trichophyton mentagrohytes colonies. Results showed that the curcuma zedoaria ekstract inhibited Trichophyton mentagrophytes. The research was continued by Minimum Inhibitory Concentration (MIC) test by liquid dilution method in Sabaroud Dekstrosa Broth. Ethanol extract curcuma zedoaria did not indicate the value of the MIC test  because due to the color and viscosity of samples which interfere with the observations. As for the positive control shows a clear color, that  indicating the presence of inhibitory Trichophyton mentagrophytes by ketokonazol. For the value of the Minimum Fungicidal Concentration (MFC) to Trichophyton mentagrophytes are present in a concentration of 50%.


Keywords


Trichophyton mentagrophytes, Curcuma zedoaria, MIC, MFC.

References


Havlickova B, Czaika VA, Friedrich M. Epidemiological trends in skin mycoses worldwide. Mycoses 2008;51:2.

Verma S, Haffernan MP. Fizpatrick's Dermatology in General Medicine. Edisi VII. New York : Mc Graw Hills, 2008.

Chen SC, Sorrel TC. New drugs, Old drugs : Antifungal agents. MJA 2007:187:404-409.

Lobo R, Prabhua KS, Shirwaikara A, Shirwaikarb A. Curcuma zedoaria rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties. Journal of Pharmacy and Pharmacology 2009; 61: 13–21.

Sumathi S, Iswariya GT, Sivaprabha B, Dharani B, Radha P, Padma PR. Comparative study of radical scavenging activity and phytochemical analysis of fresh and dry rhizomes of Curcuma zedoaria. IJPSR. 2013; 4(3): 1069–1073.

Carvalho FR, Vassão RC, Nicoletti MA, Maria DA. Effect of Curcuma zedoaria crude extract against tumor progression and immunomodulation. J Venom Anim Toxins incl Trop Dis 2010; 16(2): 324–41.

Windono MS, Parfiani N. Curcuma Zedoaria Rosc. Kajian Pustaka Kandungan Kimia dan aktivitas Farmakologik, Artocaspus 2002, 2(1) : 1–10.

Himaja M, Ranjhita A, Ramana MV, Karigar A. Phytochemical screening and antioxidant activity of rhizome part of Curcuma zedoaria. IJRAP 2010; 1(2): 414– 7




DOI: https://doi.org/10.56711/jifa.v8i2.214

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ISSN: 2085-4714 | e-ISSN: 2502-9444

Editor's Address:

Faculty of Pharmacy, Univeristas Muslim Indonesia
2nd Campus of UMI: Jl. Urip Sumoharjo km. 5 , Makassar, South Sulawesi, Indonesia

E-mail: jurnal.farmasi@umi.ac.id

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