A. Hasrawati, Aztriana Aztriana


Chili Pepper (Capsicum frutescence L) is a plant that can be used for the treatment of rheumatoid arthritis (RA). Chemical constituents contained in chili pepper is capsaicin, it was stimulate the nerves that can relieve pain. The purpose of this study was to determine the gel formulation of the ethanol extract of cayenne pepper which has optimal stability by using a variation of the base. In this study, the ethanol extract of cayenne pepper (2.5%) was made using synthetic gel base (carbopol) and semisynthetic gel base (sodium carboxymethylcellulose). Evaluation  of the physical stability was tested  using stress conditions method. The stability parameters were  determined by organoleptic, viscosity and flow type. The ethanol extract of chili pepper was successfully created  gel form by using 5% of sodium carboxymethylcellulose and 1% of carbopol as a gelling agent. There was no significant change of two formulas  in  stability  evaluation  before and after  of the storage condition.


Capsicum frutescence L, chili pepper, ethanol extract, rheumatoid arthritis


Sherwood L. Fisiologi Manusia Dari Sel Ke Sistem. Edisi 2. Penerbit Buku Kedokteran EGC : Jakarta, 1996.

Sheil WC. 2010. Rheumatoid Arthritis (RA). Available from:, diakses tanggal 28 April 2011.

Soumya R. Approach to the Patient with Musculoskeletal Disease. In: Coblyn, J.S., Bermas, B., Weinblatt, M., and Helfgott, S., Brigham & Women’s Experts’ Approach to Rheumatology. Jones & Bartlett Learning, 2011.

National Institute of Arthritis and Muskuloskeletal and Skin Disease (NIAMS). Questions and Answers about Arthritis and Rheumatic Disease. National Institute of Health : United States, 2008.

Tutik, 2010. Cabai rawit (Capsicum frutescence L), ( index .php ), diakses tanggal 10 Juli 2011.

Anonim, 2008, Ensiklopedia Indonesia, (Online), (, diakses tanggal 23 Juni 2011).

Anonim, 2010. Capsaicin, (, diakses tanggal 10 Juli 2011.

Ansel CH. Pengantar Bentuk Sediaan Farmasi. UI-Press: Jakarta, 1989.

Gennaro, A.R. Remington : The Science and Practice of Pharmacy 20thedition. Philadelphia College of Pharmacy and Science : Philadelphia, 1990.

Lund W. The Pharmaceutical Codex Twelfth Edition. The Pharmaceutical Press : London, 1994.



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ISSN: 2085-4714 | e-ISSN: 2502-9444

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Faculty of Pharmacy, Univeristas Muslim Indonesia
2nd Campus of UMI: Jl. Urip Sumoharjo km. 5 , Makassar, South Sulawesi, Indonesia


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