AKTIVITAS ANTIINFLAMASI EKSTRAK ETANOL KULIT JERUK PAMELO (Citrus maxima) TERHADAP TIKUS (Rattus novergicus) DIINDUKSI KARAGEN LAMBDA

Sukmawati Sukmawati, Ira Asmaliani, Astuti K, Hendra Herman

Abstract


Inflammation is one of the body's responses due to injury caused by various infectious agents, for example microorganisms such as bacteria, viruses, fungi, parasites and foreign. Plants contain secondary metabolites that can treat inflammation. One of the compounds known to be an anti-inflammatory agent is flavonoids. Flavonoids have an anti-inflammatory mechanism of action by inhibiting the cyclooxygenase enzyme. Pamelo orange peel (Citrus maxima) contains alkaloids, flavonoids, lycopene, vitamin C, as well as pectin and tannin. This research aims to determine the activity and effective dose of ethanol extract of pomelo orange peel as an anti-inflammatory. This research used male rats (Rattus novergicus) as test animals which were divided into 5 treatment groups, namely negative control group, positive control group were given diclofenac sodium, groups III, IV and V were given a suspension of ethanol extract of pomelo orange peel with a concentration of 150 mg/kgBB, 200 mg/kgBB and 250 mg/kgBB. Rats were induced with 0.1 mL of lambda carrageenan intraplantarly while the drug and extract were administered orally. Measurements were taken after induction at the 30th minute, 1st hour to 6th hour. The results of the study showed that the ethanol extract of pomelo (Citrus maxima) orange peel dose 150 mg/kgBW has better activity in treating inflammation in rats among the other group.


Keywords


Anti-inflammatory; Flavonoids; Pomelo Orange Peel (Citrus maxima); Lambda carrageenan; Rats.

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DOI: https://doi.org/10.56711/jifa.v17i2.1384

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