PENGUJIAN AKTIVITAS ANALGETIK INFUSA HERBA KROKOT (Portulaca oleracea L.) PADA MENCIT PUTIH (Mus musculus) MENGGUNAKAN METODE HOT PLATE

Rizqi Nur Azizah, Bayu Putra, Alda Alda

Abstract


Analgesics are substances that can reduce pain. However, long-term use may trigger side effects. This study aimed to evaluate the analgesic effect of purslane herb infusion (Portulaca oleracea L.) using a pain stimulation method and determine its effective concentration as an analgesic in white mice (Mus musculus). The research was conducted experimentally using male white mice divided into five treatment groups: Group I received Na-CMC as a negative control, Group II received paracetamol suspension as a positive control, and Groups III, IV, and V received the infusion at concentrations of 10%, 20%, and 30%, respectively. Test animals were placed on a hot plate at a temperature of 55°C, and the pain response time to heat stimulation was observed every 30 minutes for 3 hours. The data were statistically analyzed using one-way ANOVA followed by Bonferroni post hoc tests. The positive control group showed no significant differences compared to the groups receiving 10%, 20%, and 30% infusion concentrations. The study concluded that the purslane herb infusion has an analgesic effect in white mice, with an effective concentration of 30%.


Keywords


Analgesic, Herbal Infusion, Portulaca oleracea L., Hot Plate

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DOI: https://doi.org/10.56711/jifa.v16i2.1274

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