PENGARUH DOSIS EKSTRAK ETANOL DAUN KAYU JAWA (Lannea coromandelic (Houtt.) Merr.) TERHADAP AKTIVITAS ANTIINFLAMASI PADA TIKUS (Rattus norvegicus).

Abstract

In general, anti-inflammatory drugs that currently available have great side effects. One of plant that suspected have anti-inflammatory effect is Kayu Jawa (Lannea coromandelic (Houtt). Merr). Objective of this research is to determine anti-inflammatory effect and effective concentration from extract ethanol Kayu Jawa leaves. First treatment was start with rats group divided into 5 groups that initial foot volume have been measured, then 0.3 mL of 1% lambda carrageenan solution injected to rat’s left foot as inducer, then foot volume measured again. Furthermore, rat groups were given oral induction,  1^st group were given NaCMC as control group, 2^nd group were given Diclofenac Sodium as drugs control group, then 3^rd, 4^th, and 5^th as test group were given ethanol extract of Kayu Jawa leaves 75 mg/kgBW,  150 mg/kgBW, and 300 mg/kgBW. Foot volume measured again using plestimometer every 1 hour for 5 hours. The result showed that with 75 mg/kgBW, 150 mg/kgBW dan 300 mg/kgBW of ethanol extract Kayu Jawa leaves have ability to reduce rat’s foots volume that induce with carrageenan. Ethanol extract of Kayu Jawa leaves with dosage 300 mg/kgBW have bigger percentage of reducing rat’s foots volume (56.30%) than the other groups.