FORMULASI DAN EVALUASI SALEP EKSTRAK DAUN GULMA SIAM (Chromolaena odorata L.) DENGAN VARIASI BASIS SALEP

A. Hasrawati, Yasir Famir, Aztriana Aztriana, A. Mumtihanah Mursyid

Sari


Siam weed leaves are one of the plants that function as wound medicine. This study aims to produce a stable ointment dosage form. Siamese weed leaf extract is formulated in the form of ointment with a variety of bases consisting of a hydrocarbon base, absorption, water soluble and emulsion. Evaluation of physical stability includes organoleptic testing, homogeneity, pH, dispersion, viscosity and flow properties carried out before and after forced conditions. Forced conditions were carried out with stock storage for 10 cycles at 50 and 350. The results of the analysis showed that the viscosity of the preparations in all formulas changed after storage at 50 and 350 for 5 days. However, the statistical results show that all formulas did not experience significant changes between before and after the stress condition treatment.


Kata Kunci


Siamese weed (Chromolaena odorata L.), ointment, hydrocarbon base, absorption base, water soluble base, emulsion base.

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Referensi


Hernani MY, Mufrod M and Sugiyono S. Formulasi Salep Ekstrak Air Tokek (Gekko gecko L.) untuk penyembuhan luka. Majalah Farmaseutik 2012; 8(1):120-124.

Yenti R, Afrianti R and Sandi M. Formulasi Krim Ekstrak Etanol Daun Kirinyuh (Eupatorium odoratum L.) Untuk Penyembuhan Luka. J Scientia 2011;Vol. 3 (1).

Mulyani D. Perbandingan Daya Hambat Ekstrak Etanol Daun Kembang Bulan (Tithonia Diversifolia) Dengan Daun Tekelan (Chromolaena Odorata) Terhadap Bakeri Staphylococcus aureus. Scientia Jurnal Farmasi dan Kesehatan 2017;7(2):77-82.

Zulfa E, Prasetyo TB and Murukmihadi M. Formulasi Salep Ekstrak Etanolik Daun Binahong (Anrederacordifolia (Ten.) Steenis) Dengan Variasi Basis Salep. e-Publikasi Fakultas Farmasi 2015;12(2):41-48.

Parwanto ME, Senjaya H and Edy HJ. Formulasi Salep Antibakteri Ekstrak Etanol Daun Tembelekan (Lantana camara L). Pharmacon 2013;2(3).

Ali NW. Pengaruh Perbedaan Tipe Basis Terhadap Sifat Fisik Sediaan Salep Ekstrak Etanol Daun Tapak Kuda (Ipomoea pes-caprae (L) Sweet). Pharmacon 2015; 4(3):110-116.

Daisa F, Andrie M and Taurina W. The Effectiveness Test of Oil Phase Ointment Containing Snakehead Fish (Channa striata) Extract on Open Stage II Acute Wounded Wistar Strain Male Rats. Majalah Obat Tradisional (Traditional Medicine Journal) 2017; 22(2):97-102.

Banker GS and Rhodes CT. Modern Pharmaceutics, Third Edition. New York: Basel Marcel Dekker Inc, 1995.

Puspitasari AD and Proyogo LS. Perbandingan Metode Ekstraksi Maserasi dan Sokletasi Terhadap Kadar Fenolik Total Ekstrak Etanol Daun Kersen (Muntingia calabura). Cendekia Eksata 2017; 2(1).

Gennaro AR. Remington’s The Science and Practice of Pharmacy (20th ed). Philadelphia: Philadelphia Colage of Pharmacy and Science, 2000.

Hoover J. Remington Pharmaceutical Science, 18th Edition. Easton Pennsylvania : Mack Publishing Company, 1990.

Sinko PJ. Martin’s physical pharmacy and pharmaceutical science, 6th edn. Philladelphia : Wolter Kluwer, 2011.

Phan TT, Hughes MA, Cherry GW. Enhanced proliferation of fibroblasts and endothelial cells treated with an extract of the leaves of Chromolaena odorata (Eupolin), an herbal remedy for treating wounds. Plast Reconstr Surg. 1998;101(3):756-65.

Thang PT, Patrick S, Teik LS, Yung CS. Anti-oxidant effects of the extracts from the leaves of Chromolaena odorata on human dermal fibroblasts and epidermal keratinocytes against hydrogen peroxide and hypoxanthine-xanthine oxidase induced damage. Burns. 2001;27(4):319-27.


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